Research
Research interests
1) Generating reliable evidence through large-scale multi-center epidemiological studies utilizing OMOP common data model
2) Developing clinical prediction models, especially adopting cutting-edge algorithms (LLM, foundation model, etc)
3) Health data infrastructure (data standardization, harmonization, and curation) for reproducible medical research
Highlighted publications
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
JAMA
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24 Jun 2025
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doi:10.1001/JAMA.2025.4735
Semaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers
JAMA Oncology
·
01 Jan 2026
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doi:10.1001/JAMAONCOL.2025.4560
All publications
2026
GLP-1 Receptor Agonist Prescriptions for Adolescents With Obesity and Associated Disparities
JAMA Pediatrics
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01 Mar 2026
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doi:10.1001/JAMAPEDIATRICS.2025.5708
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Diabetes Mellitus
openRxiv
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24 Feb 2026
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doi:10.64898/2026.02.23.26346890
Semaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers
JAMA Oncology
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01 Jan 2026
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doi:10.1001/JAMAONCOL.2025.4560
2025
Data Resource Profile Health Insurance Review and Assessment Service Korean Nationwide Claims OMOP-CDM (2015-2024) database, "HIRA K-OMOP"
medRxiv (Under Review)
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11 Dec 2025
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doi:10.64898/2025.12.08.25341603
Clustering of patients with severe asthma based on long-term percentage of forced expiratory volume in 1 second (FEV1) changes
Annals of Allergy, Asthma & Immunology
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01 Dec 2025
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doi:10.1016/j.anai.2025.12.002
Semaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers
JAMA Oncology
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06 Nov 2025
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doi:10.1001/jamaoncol.2025.4560
Abstract 4372279: Resistant Hypertension and BP Trajectories: EHR Insights into PA and OSA Screening Practices
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4372279
Abstract 4371406: Missed Opportunities for Stroke Prevention in Hypertensive Patients: A Retrospective Case-Control Study
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4371406
Abstract 4367801: Tirzepatide Achieves Greater Weight and Blood Pressure Reduction Than Semaglutide in Routine Clinical Practice
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4367801
Prescribing of GLP-1 Receptor Agonists for Adolescents with Obesity and Associated Disparities
medRxiv (Accepted)
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07 Oct 2025
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doi:10.1101/2025.10.06.25337411
Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries
Journal of Clinical Epidemiology
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01 Sep 2025
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doi:10.1016/J.JCLINEPI.2025.111867
Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
JAMA Network Open
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08 Aug 2025
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doi:10.1001/JAMANETWORKOPEN.2025.26013
Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
JACC: Advances
·
01 Aug 2025
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doi:10.1016/j.jacadv.2025.101912
Survival Outcomes after Monitoring, Surgery, or Radiotherapy for Clinically Localized Prostate Cancer
medRxiv
·
18 Jul 2025
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doi:10.1101/2025.07.16.25331661
Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
JAMA Network Open
·
14 Jul 2025
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doi:10.1001/JAMANETWORKOPEN.2025.20498
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
JAMA
·
24 Jun 2025
·
doi:10.1001/jama.2025.4735
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
JAMA
·
24 Jun 2025
·
doi:10.1001/JAMA.2025.4735
Renal and Safety Outcomes of SGLT2 Inhibitors in Patients with Type 2 Diabetes: A Nationwide Observational Cohort Study
Journal of Clinical Medicine
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12 May 2025
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doi:10.3390/jcm14103349
Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM
medRxiv (Under Review)
·
09 May 2025
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doi:10.1101/2025.05.08.25327248
Renal and Safety Outcomes of SGLT2 Inhibitors in Patients with Type 2 Diabetes: A Nationwide Observational Cohort Study
MDPI AG
·
31 Mar 2025
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doi:10.20944/PREPRINTS202503.2260.V1
Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
eClinicalMedicine
·
01 Mar 2025
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doi:10.1016/j.eclinm.2025.103096
Impact of Regulatory Post‐Market Safety Advisories on Prescribing Practices: An Interrupted Time Series Analysis
Clinical Pharmacology & Therapeutics
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22 Feb 2025
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doi:10.1002/cpt.3614
Abstract 21: At least 1 in 4 Stroke Survivors do Not Achieve Adequate BP Control
Stroke
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01 Feb 2025
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doi:10.1161/STR.56.SUPPL_1.21
Adverse Impacts of Corticosteroid Treatment on Osteoporosis/Osteopenia in Adult Asthmatics: A Retrospective ICARUS Cohort Study
The Journal of Allergy and Clinical Immunology: In Practice
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01 Feb 2025
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doi:10.1016/J.JAIP.2024.10.016
Baseline Alpha‐Fetoprotein Elevation and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B: A Multicentre Cohort Study
Journal of Viral Hepatitis
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29 Jan 2025
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doi:10.1111/JVH.70006
A failure to launch: blood pressure control after stroke in a regional health system
Journal of Hypertension
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14 Jan 2025
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doi:10.1097/HJH.0000000000003961
Utilizing the Electronic Health Record to Evaluate Lipoprotein(a) Testing Within a Large Regional Health System
JACC: Advances
·
01 Jan 2025
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doi:10.1016/J.JACADV.2024.101441
Using Electronic Health Records to Evaluate Treatment Gaps and Disparities in Severe Hypertension
JACC: Advances
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01 Jan 2025
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doi:10.1016/J.JACADV.2024.101428
Real-World Effectiveness of Omalizumab Treatment in Adult Asthma Patients
Yonsei Medical Journal
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01 Jan 2025
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doi:10.3349/ymj.2024.0320
Gastrointestinal Adverse Effects of Second-Line Anti-Diabetic Drugs: A Federated Cohort Study
Elsevier BV
·
01 Jan 2025
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doi:10.2139/ssrn.5270424
Finding a constrained number of predictor phenotypes for multiple outcome prediction
BMJ Health & Care Informatics
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01 Jan 2025
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doi:10.1136/BMJHCI-2024-101227
2024
Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data
eClinicalMedicine
·
01 Nov 2024
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doi:10.1016/J.ECLINM.2024.102903
Combined Methylphenidate and Selective Serotonin Reuptake Inhibitors in Adults With Attention-Deficit/Hyperactivity Disorder
JAMA Network Open
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09 Oct 2024
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doi:10.1001/JAMANETWORKOPEN.2024.38398
Enhancing readmission prediction models by integrating insights from home healthcare notes: Retrospective cohort study
International Journal of Nursing Studies
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01 Oct 2024
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doi:10.1016/J.IJNURSTU.2024.104850
Abstract P137: Real-World Impact of Semaglutide on Cardiometabolic Risk Factors in Patients without Diabetes: A Multi-Center Analysis of Electronic Health Records
Hypertension
·
01 Sep 2024
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doi:10.1161/HYP.81.SUPPL_1.P137
Abstract MP20: Leveraging Electronic Health Records to Assess Neighborhood Advantages and Risk of Cardiovascular Outcomes Among Hypertensive Patients
Hypertension
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01 Sep 2024
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doi:10.1161/HYP.81.SUPPL_1.MP20
Time Series AI Model for Acute Kidney Injury Detection Based on a Multicenter Distributed Research Network: Development and Verification Study
JMIR Medical Informatics
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05 Jul 2024
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doi:10.2196/47693
Erratum to “Translation of Machine Learning-Based Prediction Algorithms to Personalised Empiric Antibiotic Selection: A Population-Based Cohort Study” International Journal of Antimicrobial Agents 62 (2023) 106966
International Journal of Antimicrobial Agents
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01 Jun 2024
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doi:10.1016/J.IJANTIMICAG.2024.107174
The risks of autoimmune- and inflammatory post-acute COVID-19 conditions: a network cohort study in six European countries, the US, and Korea
openRxiv
·
15 May 2024
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doi:10.1101/2024.05.15.24307344
Comparative effectiveness and safety outcomes between denosumab and bisphosphonate in South Korea
Journal of Bone and Mineral Research
·
09 May 2024
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doi:10.1093/JBMR/ZJAE070
Corrigendum to: Development and Verification of Time-Series Deep Learning for Drug-Induced Liver Injury Detection in Patients Taking Angiotensin II Receptor Blockers: A Multicenter Distributed Research Network Approach
Healthcare Informatics Research
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30 Apr 2024
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doi:10.4258/HIR.2024.30.2.168
Data Resource Profile: Health Insurance Review and Assessment Service Covid-19 Observational Medical Outcomes Partnership (HIRA Covid-19 OMOP) database in South Korea
International Journal of Epidemiology
·
11 Apr 2024
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doi:10.1093/IJE/DYAE062
Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries
Springer Science and Business Media LLC
·
10 Apr 2024
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doi:10.21203/rs.3.rs-4091654/v1
Comparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study
BMC Psychiatry
·
16 Feb 2024
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doi:10.1186/S12888-024-05578-6
Real-world treatment trajectories of adults with newly diagnosed asthma or COPD
BMJ Open Respiratory Research
·
01 Feb 2024
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doi:10.1136/BMJRESP-2023-002127
Real-World Effectiveness of Statin Therapy in Adult Asthma
The Journal of Allergy and Clinical Immunology: In Practice
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01 Feb 2024
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doi:10.1016/J.JAIP.2023.10.029
RHEA: Real-World Observational Health Data Exploration Application
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231251
Prediction Models for Readmission Using Home Healthcare Notes and OMOP-CDM
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231233
A De-Identification Model for Korean Clinical Notes: Using Deep Learning Models
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231242
Safety outcomes of antipsychotics classes in drug-naïve patients with first-episode schizophrenia: A nationwide cohort study in South Korea
Asian Journal of Psychiatry
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01 Jan 2024
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doi:10.1016/J.AJP.2023.103857
Incidence of Post-Acute COVID-19 Symptoms in 7 Countries: An International Network Cohort Study
Elsevier BV
·
01 Jan 2024
·
doi:10.2139/ssrn.4802680
Finding a Constrained Number of Predictor Phenotypes for Multiple Outcome Prediction
Elsevier BV
·
01 Jan 2024
·
doi:10.2139/ssrn.4874415
Comparison of deep learning and conventional methods for disease onset prediction
arXiv
·
01 Jan 2024
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doi:10.48550/arXiv.2410.10505
2023
Translation of Machine Learning-Based Prediction Algorithms to Personalised Empiric Antibiotic Selection: A Population-Based Cohort Study
International Journal of Antimicrobial Agents
·
01 Nov 2023
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doi:10.1016/J.IJANTIMICAG.2023.106966
Scalable Infrastructure Supporting Reproducible Nationwide Healthcare Data Analysis toward FAIR Stewardship
Scientific Data
·
04 Oct 2023
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doi:10.1038/S41597-023-02580-7
Development and Verification of Time-Series Deep Learning for Drug-Induced Liver Injury Detection in Patients Taking Angiotensin II Receptor Blockers: A Multicenter Distributed Research Network Approach
Healthcare Informatics Research
·
31 Jul 2023
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doi:10.4258/HIR.2023.29.3.246
Privacy-Preserving Federated Model Predicting Bipolar Transition in Patients With Depression: Prediction Model Development Study
Journal of Medical Internet Research
·
20 Jul 2023
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doi:10.2196/46165
Long‐term clinical outcomes of aspirin‐exacerbated respiratory disease: Real‐world data from an adult asthma cohort
Clinical & Experimental Allergy
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18 Jun 2023
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doi:10.1111/CEA.14362
Association of 5α-Reductase Inhibitor Prescription With Bladder Cancer Progression in Males in South Korea
JAMA Network Open
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16 May 2023
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doi:10.1001/JAMANETWORKOPEN.2023.13667
Safety Outcomes of Selective Serotonin Reuptake Inhibitors in Adolescent Attention-Deficit/Hyperactivity Disorder with Comorbid Depression: The ASSURE Study – CORRIGENDUM
Psychological Medicine
·
20 Apr 2023
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doi:10.1017/S0033291723001022
Reproducible variability: assessing investigator discordance across 9 research teams attempting to reproduce the same observational study
Journal of the American Medical Informatics Association
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24 Feb 2023
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doi:10.1093/JAMIA/OCAD009
Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: the ASSURE study
Psychological Medicine
·
20 Feb 2023
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doi:10.1017/S0033291723000120
Privacy-Preserving Federated Model Predicting Bipolar Transition in Patients With Depression: Prediction Model Development Study (Preprint)
JMIR Publications Inc.
·
01 Feb 2023
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doi:10.2196/preprints.46165
2022
Long-term methylphenidate use for children and adolescents with attention deficit hyperactivity disorder and risk for depression, conduct disorder, and psychotic disorder: a nationwide longitudinal cohort study in South Korea
Child and Adolescent Psychiatry and Mental Health
·
11 Oct 2022
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doi:10.1186/S13034-022-00515-5
Effectiveness of Maintenance and Reliever Therapy Using Inhaled Corticosteroid–Formoterol in Asthmatics
The Journal of Allergy and Clinical Immunology: In Practice
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01 Oct 2022
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doi:10.1016/J.JAIP.2022.06.009
Applying the OMOP Common Data Model to Facilitate Benefit-Risk Assessments of Medicinal Products Using Real-World Data from Singapore and South Korea
Healthcare Informatics Research
·
30 Apr 2022
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doi:10.4258/HIR.2022.28.2.112
Psychosis Relapse Prediction Leveraging Electronic Health Records Data and Natural Language Processing Enrichment Methods
Frontiers in Psychiatry
·
05 Apr 2022
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doi:10.3389/FPSYT.2022.844442
DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models
Nature Communications
·
30 Mar 2022
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doi:10.1038/S41467-022-29160-4
Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network
BMC Medical Research Methodology
·
30 Jan 2022
·
doi:10.1186/S12874-022-01505-Z
2021
A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data
Computer Methods and Programs in Biomedicine
·
01 Nov 2021
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doi:10.1016/J.CMPB.2021.106394
Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer
Pharmaceuticals
·
08 May 2021
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doi:10.3390/PH14050445
Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study
JMIR Medical Informatics
·
05 Apr 2021
·
doi:10.2196/21547
A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data
openRxiv
·
26 Mar 2021
·
doi:10.1101/2021.03.23.21254098
Longitudinal Outcomes of Severe Asthma: Real-World Evidence of Multidimensional Analyses
The Journal of Allergy and Clinical Immunology: In Practice
·
01 Mar 2021
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doi:10.1016/J.JAIP.2020.09.055
2020
Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea
The American Journal of Geriatric Psychiatry
·
01 Dec 2020
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doi:10.1016/j.jagp.2020.09.016
Machine-learning model to predict the cause of death using a stacking ensemble method for observational data
Journal of the American Medical Informatics Association
·
19 Nov 2020
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doi:10.1093/JAMIA/OCAA277
Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets
openRxiv
·
17 Jun 2020
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doi:10.1101/2020.06.15.20130328
Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study (Preprint)
JMIR Publications Inc.
·
17 Jun 2020
·
doi:10.2196/preprints.21547
Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network
openRxiv
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27 May 2020
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doi:10.1101/2020.05.26.20112649
Web of Science
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wosuid:WOS:001407925903089
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wosuid:PPRN:112578409
Web of Science
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