Research
Research interests
1) Generating reliable evidence through large-scale multi-center epidemiological studies utilizing OMOP common data model
2) Developing clinical prediction models, especially adopting cutting-edge algorithms (LLM, foundation model, etc)
3) Health data infrastructure (data standardization, harmonization, and curation) for reproducible medical research
Highlighted publications
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes
Nature Communications
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04 Apr 2026
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doi:10.1038/s41467-026-71307-0
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
JAMA
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24 Jun 2025
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doi:10.1001/JAMA.2025.4735
All publications
2026
Sex Differences in Comparative Effectiveness and Safety of Second-line Antidiabetic Agents: Real-world Evidence from Large-scale Multinational Study
openRxiv
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12 Apr 2026
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doi:10.64898/2026.04.10.26350252
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes
Nature Communications
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04 Apr 2026
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doi:10.1038/s41467-026-71307-0
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus
JACC
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01 Apr 2026
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doi:10.1016/j.jacc.2026.02.5123
GLP-1 Receptor Agonist Prescriptions for Adolescents With Obesity and Associated Disparities
JAMA Pediatrics
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01 Mar 2026
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doi:10.1001/JAMAPEDIATRICS.2025.5708
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Diabetes Mellitus
openRxiv
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24 Feb 2026
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doi:10.64898/2026.02.23.26346890
Semaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers
JAMA Oncology
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01 Jan 2026
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doi:10.1001/JAMAONCOL.2025.4560
2025
Data Resource Profile: Health Insurance Review and Assessment Service Korean Nationwide Claims OMOP-CDM (2015–2024) database,
“HIRA K-OMOP”
openRxiv
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11 Dec 2025
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doi:10.64898/2025.12.08.25341603
Clustering of patients with severe asthma based on long-term percentage of forced expiratory volume in 1 second (FEV1) changes
Annals of Allergy, Asthma & Immunology
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01 Dec 2025
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doi:10.1016/j.anai.2025.12.002
Abstract 4372279: Resistant Hypertension and BP Trajectories: EHR Insights into PA and OSA Screening Practices
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4372279
Abstract 4371406: Missed Opportunities for Stroke Prevention in Hypertensive Patients: A Retrospective Case-Control Study
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4371406
Abstract 4367801: Tirzepatide Achieves Greater Weight and Blood Pressure Reduction Than Semaglutide in Routine Clinical Practice
Circulation
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04 Nov 2025
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doi:10.1161/CIRC.152.SUPPL_3.4367801
Prescribing of GLP-1 Receptor Agonists for Adolescents with Obesity and Associated Disparities
openRxiv
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07 Oct 2025
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doi:10.1101/2025.10.06.25337411
Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries
Journal of Clinical Epidemiology
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01 Sep 2025
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doi:10.1016/J.JCLINEPI.2025.111867
Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
JAMA Network Open
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08 Aug 2025
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doi:10.1001/JAMANETWORKOPEN.2025.26013
Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
JACC: Advances
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01 Aug 2025
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doi:10.1016/j.jacadv.2025.101912
Survival Outcomes after Monitoring, Surgery, or Radiotherapy for Clinically Localized Prostate Cancer
openRxiv
·
18 Jul 2025
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doi:10.1101/2025.07.16.25331661
Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
JAMA Network Open
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14 Jul 2025
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doi:10.1001/JAMANETWORKOPEN.2025.20498
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
JAMA
·
24 Jun 2025
·
doi:10.1001/JAMA.2025.4735
Renal and Safety Outcomes of SGLT2 Inhibitors in Patients with Type 2 Diabetes: A Nationwide Observational Cohort Study
Journal of Clinical Medicine
·
12 May 2025
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doi:10.3390/jcm14103349
Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM
openRxiv
·
09 May 2025
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doi:10.1101/2025.05.08.25327248
Renal and Safety Outcomes of SGLT2 Inhibitors in Patients with Type 2 Diabetes: A Nationwide Observational Cohort Study
MDPI AG
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31 Mar 2025
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doi:10.20944/PREPRINTS202503.2260.V1
Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
eClinicalMedicine
·
01 Mar 2025
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doi:10.1016/j.eclinm.2025.103096
Impact of Regulatory Post‐Market Safety Advisories on Prescribing Practices: An Interrupted Time Series Analysis
Clinical Pharmacology & Therapeutics
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22 Feb 2025
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doi:10.1002/cpt.3614
Abstract 21: At least 1 in 4 Stroke Survivors do Not Achieve Adequate BP Control
Stroke
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01 Feb 2025
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doi:10.1161/STR.56.SUPPL_1.21
Adverse Impacts of Corticosteroid Treatment on Osteoporosis/Osteopenia in Adult Asthmatics: A Retrospective ICARUS Cohort Study
The Journal of Allergy and Clinical Immunology: In Practice
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01 Feb 2025
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doi:10.1016/J.JAIP.2024.10.016
Baseline Alpha‐Fetoprotein Elevation and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B: A Multicentre Cohort Study
Journal of Viral Hepatitis
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29 Jan 2025
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doi:10.1111/JVH.70006
A failure to launch: blood pressure control after stroke in a regional health system
Journal of Hypertension
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14 Jan 2025
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doi:10.1097/HJH.0000000000003961
Utilizing the Electronic Health Record to Evaluate Lipoprotein(a) Testing Within a Large Regional Health System
JACC: Advances
·
01 Jan 2025
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doi:10.1016/J.JACADV.2024.101441
Using Electronic Health Records to Evaluate Treatment Gaps and Disparities in Severe Hypertension
JACC: Advances
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01 Jan 2025
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doi:10.1016/J.JACADV.2024.101428
Real-World Effectiveness of Omalizumab Treatment in Adult Asthma Patients
Yonsei Medical Journal
·
01 Jan 2025
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doi:10.3349/ymj.2024.0320
Gastrointestinal Adverse Effects of Second-Line Anti-Diabetic Drugs: A Federated Cohort Study
Elsevier BV
·
01 Jan 2025
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doi:10.2139/ssrn.5270424
Finding a constrained number of predictor phenotypes for multiple outcome prediction
BMJ Health & Care Informatics
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01 Jan 2025
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doi:10.1136/BMJHCI-2024-101227
2024
Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data
eClinicalMedicine
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01 Nov 2024
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doi:10.1016/J.ECLINM.2024.102903
Combined Methylphenidate and Selective Serotonin Reuptake Inhibitors in Adults With Attention-Deficit/Hyperactivity Disorder
JAMA Network Open
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09 Oct 2024
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doi:10.1001/JAMANETWORKOPEN.2024.38398
Enhancing readmission prediction models by integrating insights from home healthcare notes: Retrospective cohort study
International Journal of Nursing Studies
·
01 Oct 2024
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doi:10.1016/J.IJNURSTU.2024.104850
Abstract P137: Real-World Impact of Semaglutide on Cardiometabolic Risk Factors in Patients without Diabetes: A Multi-Center Analysis of Electronic Health Records
Hypertension
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01 Sep 2024
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doi:10.1161/HYP.81.SUPPL_1.P137
Abstract MP20: Leveraging Electronic Health Records to Assess Neighborhood Advantages and Risk of Cardiovascular Outcomes Among Hypertensive Patients
Hypertension
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01 Sep 2024
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doi:10.1161/HYP.81.SUPPL_1.MP20
Time Series AI Model for Acute Kidney Injury Detection Based on a Multicenter Distributed Research Network: Development and Verification Study
JMIR Medical Informatics
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05 Jul 2024
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doi:10.2196/47693
Erratum to “Translation of Machine Learning-Based Prediction Algorithms to Personalised Empiric Antibiotic Selection: A Population-Based Cohort Study” International Journal of Antimicrobial Agents 62 (2023) 106966
International Journal of Antimicrobial Agents
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01 Jun 2024
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doi:10.1016/J.IJANTIMICAG.2024.107174
The risks of autoimmune- and inflammatory post-acute COVID-19 conditions: a network cohort study in six European countries, the US, and Korea
openRxiv
·
15 May 2024
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doi:10.1101/2024.05.15.24307344
Comparative effectiveness and safety outcomes between denosumab and bisphosphonate in South Korea
Journal of Bone and Mineral Research
·
09 May 2024
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doi:10.1093/JBMR/ZJAE070
Corrigendum to: Development and Verification of Time-Series Deep Learning for Drug-Induced Liver Injury Detection in Patients Taking Angiotensin II Receptor Blockers: A Multicenter Distributed Research Network Approach
Healthcare Informatics Research
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30 Apr 2024
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doi:10.4258/HIR.2024.30.2.168
Data Resource Profile: Health Insurance Review and Assessment Service Covid-19 Observational Medical Outcomes Partnership (HIRA Covid-19 OMOP) database in South Korea
International Journal of Epidemiology
·
11 Apr 2024
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doi:10.1093/IJE/DYAE062
Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries
Springer Science and Business Media LLC
·
10 Apr 2024
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doi:10.21203/rs.3.rs-4091654/v1
Comparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study
BMC Psychiatry
·
16 Feb 2024
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doi:10.1186/S12888-024-05578-6
Real-world treatment trajectories of adults with newly diagnosed asthma or COPD
BMJ Open Respiratory Research
·
01 Feb 2024
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doi:10.1136/BMJRESP-2023-002127
Real-World Effectiveness of Statin Therapy in Adult Asthma
The Journal of Allergy and Clinical Immunology: In Practice
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01 Feb 2024
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doi:10.1016/J.JAIP.2023.10.029
RHEA: Real-World Observational Health Data Exploration Application
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231251
Prediction Models for Readmission Using Home Healthcare Notes and OMOP-CDM
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231233
A De-Identification Model for Korean Clinical Notes: Using Deep Learning Models
Studies in Health Technology and Informatics
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25 Jan 2024
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doi:10.3233/SHTI231242
Safety outcomes of antipsychotics classes in drug-naïve patients with first-episode schizophrenia: A nationwide cohort study in South Korea
Asian Journal of Psychiatry
·
01 Jan 2024
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doi:10.1016/J.AJP.2023.103857
Incidence of Post-Acute COVID-19 Symptoms in 7 Countries: An International Network Cohort Study
Elsevier BV
·
01 Jan 2024
·
doi:10.2139/ssrn.4802680
Finding a Constrained Number of Predictor Phenotypes for Multiple Outcome Prediction
Elsevier BV
·
01 Jan 2024
·
doi:10.2139/ssrn.4874415
Comparison of deep learning and conventional methods for disease onset prediction
arXiv
·
01 Jan 2024
·
doi:10.48550/arXiv.2410.10505
2023
Translation of Machine Learning-Based Prediction Algorithms to Personalised Empiric Antibiotic Selection: A Population-Based Cohort Study
International Journal of Antimicrobial Agents
·
01 Nov 2023
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doi:10.1016/J.IJANTIMICAG.2023.106966
Scalable Infrastructure Supporting Reproducible Nationwide Healthcare Data Analysis toward FAIR Stewardship
Scientific Data
·
04 Oct 2023
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doi:10.1038/S41597-023-02580-7
Development and Verification of Time-Series Deep Learning for Drug-Induced Liver Injury Detection in Patients Taking Angiotensin II Receptor Blockers: A Multicenter Distributed Research Network Approach
Healthcare Informatics Research
·
31 Jul 2023
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doi:10.4258/HIR.2023.29.3.246
Privacy-Preserving Federated Model Predicting Bipolar Transition in Patients With Depression: Prediction Model Development Study
Journal of Medical Internet Research
·
20 Jul 2023
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doi:10.2196/46165
Long‐term clinical outcomes of aspirin‐exacerbated respiratory disease: Real‐world data from an adult asthma cohort
Clinical & Experimental Allergy
·
18 Jun 2023
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doi:10.1111/CEA.14362
Association of 5α-Reductase Inhibitor Prescription With Bladder Cancer Progression in Males in South Korea
JAMA Network Open
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16 May 2023
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doi:10.1001/JAMANETWORKOPEN.2023.13667
Safety Outcomes of Selective Serotonin Reuptake Inhibitors in Adolescent Attention-Deficit/Hyperactivity Disorder with Comorbid Depression: The ASSURE Study – CORRIGENDUM
Psychological Medicine
·
20 Apr 2023
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doi:10.1017/S0033291723001022
Reproducible variability: assessing investigator discordance across 9 research teams attempting to reproduce the same observational study
Journal of the American Medical Informatics Association
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24 Feb 2023
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doi:10.1093/JAMIA/OCAD009
Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: the ASSURE study
Psychological Medicine
·
20 Feb 2023
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doi:10.1017/S0033291723000120
Privacy-Preserving Federated Model Predicting Bipolar Transition in Patients With Depression: Prediction Model Development Study (Preprint)
JMIR Publications Inc.
·
01 Feb 2023
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doi:10.2196/preprints.46165
2022
Long-term methylphenidate use for children and adolescents with attention deficit hyperactivity disorder and risk for depression, conduct disorder, and psychotic disorder: a nationwide longitudinal cohort study in South Korea
Child and Adolescent Psychiatry and Mental Health
·
11 Oct 2022
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doi:10.1186/S13034-022-00515-5
Effectiveness of Maintenance and Reliever Therapy Using Inhaled Corticosteroid–Formoterol in Asthmatics
The Journal of Allergy and Clinical Immunology: In Practice
·
01 Oct 2022
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doi:10.1016/J.JAIP.2022.06.009
Applying the OMOP Common Data Model to Facilitate Benefit-Risk Assessments of Medicinal Products Using Real-World Data from Singapore and South Korea
Healthcare Informatics Research
·
30 Apr 2022
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doi:10.4258/HIR.2022.28.2.112
Psychosis Relapse Prediction Leveraging Electronic Health Records Data and Natural Language Processing Enrichment Methods
Frontiers in Psychiatry
·
05 Apr 2022
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doi:10.3389/FPSYT.2022.844442
DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models
Nature Communications
·
30 Mar 2022
·
doi:10.1038/S41467-022-29160-4
Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network
BMC Medical Research Methodology
·
30 Jan 2022
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doi:10.1186/S12874-022-01505-Z
2021
A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data
Computer Methods and Programs in Biomedicine
·
01 Nov 2021
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doi:10.1016/J.CMPB.2021.106394
Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer
Pharmaceuticals
·
08 May 2021
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doi:10.3390/PH14050445
Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study
JMIR Medical Informatics
·
05 Apr 2021
·
doi:10.2196/21547
A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data
openRxiv
·
26 Mar 2021
·
doi:10.1101/2021.03.23.21254098
Longitudinal Outcomes of Severe Asthma: Real-World Evidence of Multidimensional Analyses
The Journal of Allergy and Clinical Immunology: In Practice
·
01 Mar 2021
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doi:10.1016/J.JAIP.2020.09.055
2020
Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea
The American Journal of Geriatric Psychiatry
·
01 Dec 2020
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doi:10.1016/j.jagp.2020.09.016
Machine-learning model to predict the cause of death using a stacking ensemble method for observational data
Journal of the American Medical Informatics Association
·
19 Nov 2020
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doi:10.1093/JAMIA/OCAA277
Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets
openRxiv
·
17 Jun 2020
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doi:10.1101/2020.06.15.20130328
Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study (Preprint)
JMIR Publications Inc.
·
17 Jun 2020
·
doi:10.2196/preprints.21547
Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network
openRxiv
·
27 May 2020
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doi:10.1101/2020.05.26.20112649
Web of Science
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